Our latest publication presents the scientific principles of our new digital PCR method - binding all nucleic acids present in a sample to magnetic nanoreactor beads. The beads provide a high-capacity binding matrix and act as compartments for PCR amplification of individual nucleic acid targets.
The BLINK approach to multiplexing is unique. BLINK Beads allow completely new approaches for multiplexing with a drastic increase of multiplexing grade while minimising the effort in building panels.
The analysis of the sheer quantity of thousands of parallel reactions with the help of the Poisson distribution allows highly reproducible results over several log levels.
The technique shares similarities with qPCR but differs in two key aspects – the preparation of the PCR reactions and the method to determine whether DNA amplification has been successful.