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The BLINK One is a cartridge-based platform that integrates BLINK Bead assays into a fully automated sample-to-answer system without the need for laboratory infrastructure. The system enables highly multiplexed molecular assays in 15 minutes.
The BLINK One is a fully integrated instrument for processing BLINK Bead-based assays on the BLINK One Cartridge. The One platform comprises a cartridge and instrument.
The system allows for direct transfer of BLINK Bead assays developed on the BLINK X system into a closed, self-contained test format that features multiplex digital PCR and integrated nucleic acid extraction. The One Cartridge is a fully functional pre-assembled unit that is filled with the assay specific BLINK Beads and generic reagents necessary to run a test.
The BLINK One Instrument is designed to process a variety of Bead assays on the BLINK One Cartridge. The Instrument is equipped with a Peltier-based incubation module for rapid PCR featuring heating and cooling ramps of >30K / sec.
Its integrated fluorescence micro-imager has four LED/Filter combinations available for Bead decoding and PCR signal detection. The Instrument is also equipped with a valve and pump actuator, a magnetic actuator for Bead handling and an additional temperature control for the heat lysis module.
The One Cartridge is closed system designed to accommodate a broad range of sample types and sample volumes. It is equipped
with a pump and rotary valve to provide for flexible liquid handling workflows.
It features storage chambers for liquid (lysis and binding buffer, re-suspension of buffer PCR pellet) and solid reagents (PCR pellet, lyophilised Beads).
The Cartridge design allows for heat lysis by heating a sample to 95°C and for mechanical lysis with an integrated bead mill. It is equipped with a module to facilitate seamless suspension of BLINK Beads in an oil matrix for dPCR and detection.
Currently BLINK’s technologies and products are accessible through strategic collaborations with BLINK as a development partner in selected application areas. Test developers and researchers will be able to develop their assays and applications independently on the BLINK X platform utilising validated components while maintaining design flexibility.